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Toshiharu Horie Selected Research

ONO 1206

12/2002Correlation between methotrexate-induced intestinal damage and decrease in polyamine content.
7/2002A synthetic analog of prostaglandin E(1) prevents the production of reactive oxygen species in the intestinal mucosa of methotrexate-treated rats.

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Toshiharu Horie Research Topics

Disease

5Mitochondrial Diseases (Mitochondrial Disease)
10/2015 - 05/2006
5Body Weight (Weight, Body)
10/2011 - 01/2002
4Chemical and Drug Induced Liver Injury
04/2016 - 06/2007
4Inflammation (Inflammations)
11/2010 - 07/2002
3Neoplasms (Cancer)
04/2009 - 06/2003
2Hepatocellular Carcinoma (Hepatoma)
01/2018 - 04/2016
2Porphyrias (Porphyria)
01/2018 - 06/2007
2Liver Failure
06/2012 - 01/2011
2Cholestasis
01/2011 - 08/2010
2Colitis
03/2008 - 04/2004
1Infections
01/2018
1Porphyria Cutanea Tarda
01/2018
1Cardiotoxicity
09/2016
1Diabetes Complications
09/2016
1Iron Overload
02/2015
1Mucositis
10/2013
1Lactic Acidosis
03/2013
1Malaria
12/2012
1Breast Neoplasms (Breast Cancer)
10/2011
1End Stage Liver Disease
01/2011
1Cardiomyopathies (Cardiomyopathy)
01/2010
1Diarrhea
04/2009
1Hepatitis
06/2007
1Acute Kidney Injury (Acute Renal Failure)
06/2006
1Inborn Genetic Diseases (Disease, Hereditary)
10/2005
1Hyperbilirubinemia
02/2005
1Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
04/2004
1Rheumatic Diseases (Rheumatism)
06/2003
1Enterocolitis
07/2002

Drug/Important Bio-Agent (IBA)

7Pharmaceutical PreparationsIBA
10/2015 - 04/2004
5Proteins (Proteins, Gene)FDA Link
01/2018 - 05/2009
4Methotrexate (Mexate)FDA LinkGeneric
10/2013 - 07/2002
3Messenger RNA (mRNA)IBA
04/2016 - 08/2010
3LipopolysaccharidesIBA
08/2010 - 04/2004
3Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
03/2008 - 04/2004
3EnzymesIBA
03/2008 - 04/2004
2Doxorubicin (Adriamycin)FDA LinkGeneric
09/2016 - 01/2010
2Troglitazone (Rezulin)FDA Link
11/2013 - 05/2006
2Salicylic Acid (2 Hydroxybenzoic Acid)FDA LinkGeneric
11/2013 - 02/2010
2Reactive Oxygen Species (Oxygen Radicals)IBA
11/2010 - 07/2002
2EndotoxinsIBA
03/2008 - 04/2004
2GalactosamineIBA
04/2004 - 01/2002
2ONO 1206IBA
12/2002 - 07/2002
1PorphyrinsIBA
01/2018
1Uroporphyrinogen Decarboxylase (Uroporphyrinogen III Decarboxylase)IBA
01/2018
13-deoxyglucosoneIBA
09/2016
1Bile Acids and Salts (Bile Acids)IBA
04/2016
1ferric nitrilotriacetateIBA
02/2015
1Ru 360IBA
02/2015
1AcidsIBA
02/2015
1Fatty Acids (Saturated Fatty Acids)IBA
11/2013
1Diclofenac (SR 38)FDA LinkGeneric
11/2013
1Claudin-4IBA
10/2013
1Phenformin (Fenformin)IBA
03/2013
1CreatinineIBA
10/2011
1Aromatase InhibitorsIBA
10/2011
1Letrozole (Femara)FDA LinkGeneric
10/2011
1BilirubinIBA
10/2011
1radixinIBA
01/2011
1Membrane Proteins (Integral Membrane Proteins)IBA
01/2011
1Peroxidase (Myeloperoxidase)IBA
11/2010
1Glutathione (Reduced Glutathione)IBA
08/2010
1Multidrug Resistance-Associated Protein 2IBA
08/2010
1Adenosine Triphosphate (ATP)IBA
02/2010
1Advanced Glycation End ProductsIBA
01/2010
1pentosidineIBA
01/2010
1N(6)-carboxymethyllysine (carboxymethyllysine)IBA
01/2010
1Biomarkers (Surrogate Marker)IBA
01/2010
1Nitric Oxide (Nitrogen Monoxide)FDA Link
03/2008
1Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
03/2008
1CytokinesIBA
03/2008
1Interleukin-6 (Interleukin 6)IBA
03/2008
1Sulfonic AcidsIBA
03/2008
1nimesulide (Aulin)IBA
03/2008
1Cytochrome P-450 CYP1A2 (CYP1A2)IBA
03/2008
1Cytochrome P-450 CYP2E1 (CYP2E1)IBA
03/2008
1Ferrochelatase (Heme Synthetase)IBA
06/2007
1AutoantibodiesIBA
06/2007
1DihydralazineIBA
06/2007
1Griseofulvin (Grifulvin V)FDA LinkGeneric
06/2007
1Heme (Haem)IBA
06/2007
1ProtoporphyrinsIBA
06/2007
1Ticrynafen (Tienilic Acid)IBA
06/2007
1Cytochrome P-450 CYP2C9IBA
06/2007
1Cisplatin (Platino)FDA LinkGeneric
06/2006
1ThiazolidinedionesIBA
05/2006
1GlucuronidesIBA
02/2005
1Dextran SulfateIBA
04/2004
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
04/2004
1Biological ProductsIBA
04/2004
1Drinking WaterIBA
04/2004
1Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
06/2003
1Antineoplastic Agents (Antineoplastics)IBA
07/2002
1ProstaglandinsIBA
07/2002

Therapy/Procedure

3Drug Therapy (Chemotherapy)
04/2009 - 06/2003
1African Traditional Medicine (Medicine, African)
12/2012
1Therapeutics
01/2010
1Punctures
01/2002